Hilton brands Hilton Hotels & Resorts, LXR and Conrad will be integrated into the $4.3bn resort.
Resorts World Las Vegas president Scott Sibella said: “With our commitment to redefining the luxury hotel standard in Las Vegas , it was only natural for us to partner with Hilton, a leader in the global hospitality industry.”
Hilton and Resorts World Las Vegas aim to recapture the character of the Las Vegas Hilton, which was once the largest hotel in the world.
The 3,500 room resort is expected to open in summer of 2021.
Hilton President, Global Development, Architecture, Design & Construction Ian Carter said: “This will mark our largest multi-brand deal in company history, and we are excited to work with our new partners to create a distinct hotel experience in an unbeatable location for our future guests and Hilton Honors members."
Earlier this week Resorts World Las Vegas announced it will partner with Konami Gaming to operate its gaming system.
The resort will include 110,000 square feet in casino floor space.
