Playtech has launched its online casino games with bet365 in New Jersey, following licensing approval last month.
A number of Playtech's biggest titles will now be available on the bet365 catalogue in the Garden State.
This is Playtech's first venture into the US market, having waited considerably longer than other market entrants.
A bet365 spokesperson said: “We’re excited to partner with Playtech to expand our content offering to the US market.
"We look forward to developing upon our already solid partnership as we continue to grow our casino offering.”
Shimon Akad, Playtech COO, said: “This is a significant moment for Playtech and our development in the US.
"This launch also serves as a prime example of our commitment to partnering with leading operators to bring software services and content to new and growing markets.”