James had been in his role at the Connecticut-based casino for just eight months, taking over from Rodney Butler who had been interim CEO, after previous incumbent Felix Rappaport died in June 2018.
A statement from the Mashantucket Pequot Tribal Nation said James has resigned to spend more time with his family, with tribal member and SVP of Resort Operations at Foxwoods, Jason Guyot, taking over as interim CEO during the search for a permanent successor.
The statement added: "The Tribal Council believes that together with our talented executive team, Foxwoods will continue to focus on managing through the remainder of the COVID-19 crisis and the re-opening of our facilities at an appropriate time in a way that prioritizes the health and safety of the members of the Mashantucket Pequot Tribal Nation, our Team Members, and the public as a whole.
“We are currently focused on a strategic reopening plan, which will take into consideration safe and social distancing guidelines. We will share updates as our plans are solidified."
The COVID-19 outbreak has had a significant impact on casinos, with closures causing Foxwoods to furlough more than 5,000 employees.
Connecticut Governor Ned Lamont recently rejected a request for tribes to offer online gaming during the lockdown period.
